The ELOF(1)ant in the room of TCR

Carnie C and Jackson SP

Nature Cell Biology 23, 584-586

Transcription-coupled repair of DNA lesions takes place across all domains of life. A transcription-elongation factor, ELOF1, highly conserved in eukaryotes, has now been shown to play a key role in this process. Importantly, these findings also include evidence of a second transcription-coupled repair pathway in mammalian cells.

News & Views on “Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability”, Geijer et al, and “ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation”, van Der Weegen Y et al.