We, with a group of international collaborators, have identified a novel protein complex (Shieldin) that promotes DNA repair in cells lacking the HR protein BRCA1.

The study, published in Nature Cell Biology identifies the ‘Shieldin’ complex, so-called because
it shields the ends of broken DNA and regulates DNA repair. Testing the levels of Shieldin in
tumours could help predict whether they will respond to anti-cancer drugs called PARP
inhibitors.