Paxx/Xlf double-knockout mice display embryonic lethality associated with genomic instability

In a paper by Balmus et al., the authors report that Paxx/Xlf double-knockout mice display embryonic lethality associated with genomic instability, cell death in the central nervous system, and an almost complete block in lymphogenesis, phenotypes that closely resemble those of Xrcc4−/− and Lig4−/− mice.