Recent years have provided an amazing advancement in the field of the ubiquitin and ubiquitin-like modifications (Ubls), as the technologies to detect them in different biological settings have improved significantly. Further, our understanding of the ubiquitin proteasome system (UPS) as a key player in essentially every aspect of biology and its potential to impact human health is now undergoing dramatic revolution in the ability to harness this system to clinical applications with the emergence of numerous proteolytic-targeting chimeras, as therapeutic modalities for human diseases ranging from cancer to infectious disease, autoimmunity and neurodegeneration. The exceptional interest in this field stems from the central role of these modifications in cell, tissue, and organismal homeostasis.

This workshop will explore the role Ub and Ubls play in different biological settings, in physiology and pathology to reveal new insight into the mechanisms that they regulate and disease-associated aberrations. The primary goals of this EMBO Workshop will be:

i) Present an overview of current knowledge with the latest research discoveries and cutting-edge approaches

ii) Foster the development of trainees and junior scientists

iii) Discuss opportunities to accelerate translational research and therapeutic development