This long-running conference will explore the latest discoveries in recombination, a fundamental DNA repair process that plays essential roles in the replication, maintenance, evolution, and transmission of the genome. As the sole meeting dedicated to this specific field of research, presentations will focus on mechanisms of homologous recombination in various cellular contexts, genome instability, and links between recombination and human disease, especially aging and cancer. The program will convene diverse scientists from all career stages studying multifarious aspects of recombination and genome maintenance, using a wide range of biological systems and experimental approaches. 

Focusing on cutting-edge advances from early-career investigators (particularly those from historically excluded groups), attendees will hear a wide array of keynotes, presentations, and panel discussions, as well as opportunities for short talks and networking. 

Goals and Takeaways

• Mechanisms of homologous recombination, from initiation to completion.

• Genome rearrangements, specifically regarding mechanisms and consequences.

• The interplay between recombination with other cellular processes.

Program Topics

• Molecular mechanisms that underpin each step in the recombination reaction 

• Telomere metabolism, genome rearrangements, aging, and tumorigenesis 

• Replication- and transcription-associated recombination

• Meiotic recombination, gamete quality, and fertility

• Regulation of recombination by post-translational protein modification 

• The role of chromatin structure on recombination and DNA damage signaling