This conference, we aim to bring together scientists studying DNA replication, DNA repair and chromosome segregation with those interested in how chromosomal instability can influence human pathology. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities.

Key Sessions

• Pathways for repair of DNA damage and disrupted DNA replication forks

• Screening tools for analysis of genome maintenance pathways and for development of new therapeutics

• Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins

• Chromosome instability as a driver of tumorigenesis, neurodegeneration and ageing

• Exploitation of defects in chromosome maintenance in cancer treatment