We are pleased to announce our fourth conference on perturbations at scale to understand genomes.

The rapid development of CRISPR/Cas-based technologies and DNA synthesis makes it possible to modulate genomes with relative ease. These tools can help us understand how genetic variation influences phenotype and thereby answer long-standing questions in biology that impact human health, laying the foundations for precision medicine for heritable diseases and cancer treatment. This advancement in gene-editing technology enables us to understand the functional implications of natural and disease-related human genetic variation.

This year’s programme will once again cover emerging technologies and models, including computational approaches. In addition, we will highlight the recent advances in precision genome editing and protein engineering methods and discuss using the applications of CRISPR/Cas-based functional genomics to identify new drug targets.

The meeting will bring together biomedical researchers working on high throughput screening, genome engineering, and/or variant effect interpretation.

This conference will be a hybrid meeting – with onsite or virtual attendance.