The Gordon Research Conference (GRC) on Genomic Instability is designed to address both the fundamental mechanisms and translational impact of the cellular pathways that maintain genome stability. Genomic instability contributes to the development of many human diseases, such as cancer, neurodegeneration, and premature ageing. This conference will present the latest research on the molecular causes of genomic instability in various human diseases, ranging from DNA replication defects to R-loop biogenesis. We will also cover the cutting-edge findings of DNA repair and DNA damage signaling pathways, their roles in counteracting different forms of genomic instability, and their deficiencies in human diseases. Furthermore, we will hear new strategies that exploit genomic instability of human diseases, bringing the findings of basic research to disease therapy. This GRC thus provides broad coverage of the field of Genomic Instability with a speaker line-up of leading scientists. In addition, each session will include several short talks to be selected from submitted abstracts. We strongly encourage researchers from under-represented communities (URMs) to participate. The Genomic Instability GRC will be preceded by a Gordon Research Seminar for trainees on July 9-10, 2022.