DNA repair and damage response pathways provide essential defensive measures against insults to a cell’s genetic material. In this function, they protect and restore genome integrity by means of a variety of mechanisms adapted to a diverse set of lesions. However, DNA repair systems also critically impinge on other cellular processes. They contribute to accurate DNA replication, they help resolve conflicts arising from the presence of RNA in chromatin, and they are co-opted for gene regulatory purposes. The influence of DNA repair pathways on cell fate contributes to phenomena such as cancer and ageing. Finally, as genome maintenance mechanisms can prevent or promote mutagenesis, they are important regulators of evolution, as they modulate the genetic diversity that natural selection draws upon.

This 4-day conference, taking place at the Institute of Molecular Biology (IMB) in Mainz, will bring together leading scientists in the field of DNA repair, damage signalling and related research areas. It will focus on the diverse aspects of cellular metabolism that genome maintenance mechanisms impinge on, thereby approaching the classical “3R” (Replication - Recombination - Repair) theme from a new angle. It will feature sessions on:

• Maintaining the chemistry of DNA

• Taking care of breaks & ends

• Promoting genome replication

• Keeping RNA in check

• Controlling gene expression

• Modulating genome plasticity

• Ensuring healthy ageing