The human genome is constantly threatened by DNA damage and replication stress. In normal cells, a variety of DNA repair pathways are used to protect the genome against different types of DNA damage and replication stress. When these repair pathways go awry, genomic instability will arise, giving rise to diseases ranging from rare developmental and premature aging syndromes to common cancers. This Mammalian DNA Repair Gordon Research Conference (GRC) and associated Gordon Research Seminar (GRS) will bring together diverse researchers studying the mechanisms that protect the human genome, and the implications of these mechanisms in human diseases and therapies. In addition, the conference will promote discussions on how to target defects in the DNA damage response in cancer therapy, and how to gain a better understanding of tumor evolution and therapeutic responses through genomic approaches.

A diverse cadre of invited speakers will present new discoveries, approaches, and concepts at the frontier of mammalian DNA repair. Additionally, multiple speakers will be selected from abstract submissions and vigorous poster sessions will provide opportunities for sharing participants' latest research. This GRC will continue a strong tradition of welcoming young scientists, connecting new and senior members of the field, and engaging all participants in discussion through an open atmosphere of scientific exchange.

Applications from investigators interested in all aspects of DNA metabolism and genome stability from basic mechanisms to clinical intervention are encouraged. Trainees are encouraged to attend this GRC and the associated GRS.