From Targets to Therapeutics

Genome Engineering, including zinc-finger nucleases, TALENs and most recently CRISPR/Cas9, has become a powerful tool in the drug discovery pipeline. This meeting will focus on the application of genome engineering to identify novel drug targets through large scale CRISPR based functional genomics studies, developing advanced cellular and in vivo disease models for target validation, and the pioneering applications in therapeutic genome editing. A current perspective of the applications of these rapidly developing technologies with a focus on drug discovery applications will be the meeting’s focus. The scientific program for this CRISPR in Drug Discovery meeting will include:

• Large-scale CRISPR functional genomics studies for drug target identification and validation

• Application of genome engineering in developing biological models of disease from single cells through to complex in vitro tissue systems and in vivo models

• Cutting edge CRISPR genome engineering technologies and their emerging applications

• A perspective from technology leaders toward the future therapeutic applications of genome engineering