The DNA in our cells constantly changes its structure and chemical composition in the course of endogenous processes and in response to exogenous challenges. The 2017 Mammalian DNA Repair GRC will expose researchers at all levels (faculty, researchers from industry, postdoctoral fellows, graduate students) to new frontiers of this rapidly progressing research field. DNA repair pathways are intimately linked to genome sequence and all aspects of DNA metabolism from replication, transcription to dynamic chromatin structural changes throughout the cell cycle. This meeting will focus on the balance between the normal cellular processes and DNA repair events in mammals to illustrate how genome integrity is safeguarded and what causes various types of instability and malady.